NIST researchers, including Summer Undergraduate Research Fellow Henry Nonnemaker, have developed a new method to measure fluid flow rates as slow as one nanoliter per minute. The technique uses lasers and mathematical analysis to track fluorescent dye molecules as they photobleach in a flowing fluid. By measuring the light re-emitted by the dye, scientists can calculate flow rates with greater precision. This advancement addresses challenges in measuring ultra-slow flows, critical for medical applications like targeted drug delivery and emerging cell manipulation technologies. The method also has potential applications in chemistry, such as improving substance separation techniques. Nonnemaker’s work focused on simulating dye movement through the system, enhancing understanding of flow dynamics. The research highlights collaboration between NIST engineers and mathematicians to refine measurement technologies for precision medical and scientific uses.
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